Effect of Centella asiatica L
نویسندگان
چکیده
In the present study the effect of Centella asiatica L. extract was studied against the genotoxic doses of ethinylestradiol on human lymphocytes culture. The different doses of C. asiatica L. extract i.e. 1.075×10 -4 , 2.125×10 -4 and 3.15×10 -4 g/ml were treated separately with 5 μM of ethinylestradiol. Similar treatments were given with 10 μM of ethinylestradiol. The treatments result in a significant dose dependent decrease in chromosomal aberrations and sister chromatid exchanges on human lymphocyte cultures induced by 5 and 10 μM of ethinylestradiol. The selected doses of C. asiatica L. extract were not genotoxic itself. Hence it is concluded that C. asiatica L. extract reduced the genotoxic damage during the ethinylestradiol therapy in patients and thereby reducing the chances of cancer development in humans.
منابع مشابه
Micropropagation of Gotu kola (Centella asiatica L.) through runner tip culture.
This article has no abstract.
متن کاملNitric Oxide radical scavenging assay of bioactive compounds present in methanol Extract of Centella asiatica
Centella asiatica L. has been used as a medicinal herb for thousands of years in India, China, Sri lanka, Nepal and Madagascar. Centella asiatica is one of the chief herbs for treating skin problems, to heal wounds, for revitalizing the nerves and brain cells, hence primarily known as a "Brain food" in India. In India, it is described under the name of Mandukaparni and used in Ayurveda medicine...
متن کاملEffect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models
Hyperlipidemia and many other metabolic diseases are related to oxidative stress. Centella asiatica is a traditional Chinese medicine whose antioxidant effect in vitro has been reported. We are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism. Therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemi...
متن کاملCentella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential
This paper covers the studies relevant to neuroprotective activity of Centella asiatica (L.) Urban, also known as "Gotu Kola." The plant is native to the Southeast Asia and has been used traditionally as brain tonic in ayurvedic medicine. The neuroprotective effect of C. asiatica has been searched using the key words "Centella, Centella asiatica, gotu kola, Asiatic pennywort, neuroprotection, a...
متن کاملAssessment report on Centella asiatica (L.) Urban, herba
Herbal preparation(s) The following designations are synonyms to define a highly refined and purified ethanolic (70% V/V) extract containing asiaticoside (40%) and 60% of triterpenic genins: asiatic acid (29-30%), madecassic (acid 29-30%) and madasiatic acid (about 1%). TECA (titrated extract of Centella asiatica) TTFCA (total triterpenoid fraction of Centella asiatica) TTF (total triterpenic f...
متن کاملEffect of Centella asiatica L. extract Against Ethinylestradiol- induced Geno toxic Damage on Cultured Human Lymphocytes
In this study the effect of Centella asiatica L. extract was studied against genotoxic doses of ethinylestradiol on human lymphocytes culture. The different doses of C. asiatica L. extract i.e. 1.075x10-4, 2.125x10-4 and 3.15x10-4 g/ml were treated separately with 5 μM of ethinylestradiol. Similar treatments were given with 10 μM of ethinylestradiol. The treatments result in a significant dose ...
متن کامل